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Archive for genetics

I think that the national discussion about racism and health care reform gets so abstract sometimes that we forget that when we’re talking about health, we’re talking about people’s lives. And, as this short clip (about 4 minutes) demonstrates very powerfully, leading researchers contend that racism plays an important role in infant mortality among African American women, even when controlling for income and education. This clip, from Episode 2, “When the Bough Breaks,” in the video series “Unnatural Causes,” (2007), features UCLA obstetrician and gynecologist Dr. Michael Lu. Lu believes that for many women of color, racism over a life time, not just during the nine months of pregnancy, increases the risk of preterm delivery, one of the leading risk factors for early infant death:

And, in an interesting piece of research by one of the experts featured in the full episode, Dr. Camara Jones, concludes that: “being classified by others as White is associated with large and statistically significant advantages in health status, no matter how one self-identifies.” So, there’s a very real, somatic level at which racism both takes a toll on some and provides an advantage to others.

I think we should keep this in mind as the health care debate rages on. What kind of society do we want to create?

Feb
03

Is White Racism Skin Deep?

Posted by: Joe | Comments (0)

Blue nevus (3 of 4)
Creative Commons License photo credit: euthman

NPR just did an interesting story on research on melanin and skin color shifts over relatively short evolutionary time, just a few thousand years. Those of us with darker skins may well have had ancestors just 2500 or so years ago who were much lighter in skin color, and those of us with lighter skin may have had much darker recent ancestors. The new research suggests that human evolution does not need thousands of years to change something as superficial as skin color. Given that reality, it is amazing and sad that we humans make so much of our thinking and social organization hinge on something as superficial as melanin variation and dark/light skin color.

Here is an interesting map (NPR, George Chaplin) of where darker-skinned people now live on the planet. Notice how skin color generally follows the levels of ultraviolet radiation (sun intensity) on the planet.

The NPR story quotes Anthropology Professor Nina Jablonski at Penn State, who argues that your current skin color

is very probably not the color your ancient ancestors had — even if you think your family has been the same color for a long, long time. … Skin has changed color in human lineages much faster than scientists had previously supposed, even without intermarriage, Jablonski says. …By creating genetic “clocks,” scientists can make fairly careful guesses about when particular groups became the color they are today. And with the help of paleontologists and anthropologists, scientists can go further: They can wind the clock back and see what colors these populations were going back tens of thousands of years, says Jablonski. She says that for many families on the planet, if we look back only 100 or 200 generations (that’s as few as 2,500 years), “almost all of us were in a different place and we had a different color.” … “People living now in southern parts of India [and Sri Lanka] are extremely darkly pigmented,” Jablonski says. But their great, great ancestors lived much farther north, and when they migrated south, their pigmentation redarkened.

Of course, we are all Africans if we go back about 100,000 years, and thus we all come from people who were once likely quite dark-skinned, given that we originated Africa
Creative Commons License photo credit: Hitchster

in equatorial Africa where the levels of ultraviolet light were, and are quite high. Melanin is a type of skin molecule that makes

skin lighter or darker. Kind of like a Venetian blind, it can let UV light in or keep it out. . .. .Humans have had it for a long, long time and what Jablonski and others have learned is that when early humans migrated from the equator, their melanin levels changed.

And skin color can change much faster than earlier estimates suggested:

“Our original estimates were that [skin color changes] occurred perhaps at a more stately pace,” Jablonski says. But now they’re finding that a population can be one color (light or dark) and 100 generations later — with no intermarriage — be a very different color. Figuring 25 years per generation (which is generous, since early humans walked naked through the world — clothes slow down the rate), that’s an astonishingly short interval.

One thing that the NPR story does not deal with is that there is some significant variation in the map, with some far-north peoples having darker skin color than those somewhat to their south. One reason for this, a science blogger suggests, is that of nutrition and agricultural development:

The deleterious consequences of switching many non-agricultural populations to the starch rich diet are well known (obesity, diabetes, etc.). Selection happens, and it seems likely that a genetic revolution was ushered in by the radically altered nutritional universe of the farmer. … Frank W. Sweet published an essay in 2002 which offered that the feasibility of a farming lifestyle at very high latitudes in Europe due to peculiar climatological conditions served to drive Europeans to develop light skins over the last 10,000 years. In short, Sweet argues that the diets of pre-farming peoples were richer in meats and fish which provided sufficient Vitamin D so that skin color was likely light brown as opposed to pink. But with the spread of agriculture Vitamin D disappeared from the diets of northern European peoples and so only by reducing their melanin levels could they produce sufficient amounts of this nutrient to keep at bay the deleterious consequences of deficiencies. This explains why the Sami, who [live far north on the planet] never adopted agriculture, remained darker.

So, sociological factors loom large as well, in this case shifts in agriculture and food eaten. There are other environmental and genetic diversity factors as well, such as timing in evolution and genetic diversity in the initial population. And one must be careful about arguing from biological research on melanin to broader sociological issues.

Still, it never ceases to amaze me that melanin variation is such a powerful factor in the social construction of “race” among human beings, so much so that young people like Mr. Grant are now deceased because of melanin variation’s perception in some white person’s mind. How irrational is that?
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Aug
21

Race and Medicine

Posted by: Jessie | Comments (3)

We seem to be pursuing a theme here today, albeit an unintentional one, with race and medicine. In the medical field, there’s something that’s referred to as “personalized medicine.” This is the idea that doctors will (some day) be able to individually tailor medical care to the patient’s needs based on an individual-level analysis of the individual’s genome. Now, some are suggesting that this “personalized medicine” should replace racial classification. Sharon Begley writing in “LabNotes” for Newsweek, says:

…a new paper published online this week by the journal Clinical Pharmacology & Therapeutics, .. concludes that classifying people by the crude category of race—as in, of African, Asian or European ancestry—for medical purposes, as some people want to do, is really, really stupid.

The article Begley refers to, “Individual Genomes Instead of Race for Personalized Medicine,” reports on the results of the sequencing of the genes of two white guys – Craig Venter and James Watson (yes, the same Watson) – to see how they metabolize six different drugs. The results were revealing.

What they found is that these two men, ostensibly of the “same race,” in fact have very different genetic make-ups when it comes to how their bodies process certain drugs. What these geneticists conclude is consistent with what social scientists have been saying for some time: “race” is social category, not a meaningful biological category. In the words of the authors of the study:

…race/ethnicity should be considered only a makeshift solution for personalized genomics because it is too approximate; known differences may occur within a defined category. …The label “African” or “African-American” is therefore insufficient to determine whether an individual comes from a population with a high frequency of the *17 allele. Even if an individual is known to be, for example, Ethiopian rather than Zimbabwean, the ancestry is less relevant than the true genotype, which could be easily resolved with today’s technology. Even the term “Caucasian” can be deceptive. If a self-identified Caucasian originates from a founder population in which certain disease-specific alleles occur at higher frequencies (e.g., Quebec French Canadians or Ashkenazi Jews), his or her doctor may miss an important aspect of the patient’s medical history. One’s ethnicity/race is, at best, a probabilistic guess at one’s true genetic makeup.

I have to say, I feel quite vindicated, given the little dust-up back in November 2007 (see the comments) with guys who wanted to argue that the “reality of race is genetic.” Still, it’s deeply ironic that this news should come from Venter and Watson, not known for their forward thinking on race (see my earlier posts about both of them here and here). But hey, I’ll take it.

Categories : genetics, race, whites
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